Conductive polyurethane/PEGylated graphene oxide composite for 3D-printed nerve guidance conduits

Conductive polymeric nanocomposites have made significant contributions in nerve regeneration. To this aim, the best results are obtained by using guidance conduits (NGCs) with conductive, bio-compatible, bio-degradable tubes as well special topographical features. In study, biodegradable, solvent-free polyurethane/PEGylated graphene oxide (PU/PEG-GO) composites were synthesized and successfully 3D printed into flexible different precise geometries, such hollow, porous, grooved tubes, stereolithography. The composite containing 5% PEG-GO showed highest tensile stress (3.51 ± 0.54 MPa), strain at break (∼170%), conductivity (1.1 × 10−3 S/cm) lowest contact angle of 72° attributing to strong interfacial interactions between nanosheets PU matrix. Moreover, PU/PEG-GO exhibited higher compression strength compared pure appropriate enzymatic degradation after 6 weeks, which is expected last sufficiently for an efficient Altogether 3D-printed, conduit geometry has potential NGCs peripheral